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In this case the novel and important point might be the implementation of the concept of cytoprotection (for review, see [1,3,4,5,6,9,32,33,34,92])

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The tesamorelin literature is the cautionary comparison — it took 410 randomised patients and 26-week extension phases totalling 52 weeks of treatment to establish an effect on an actual endpoint, and even then the effect vanished on discontinuation [10]

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