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- A toxicity study of SFN supplementation carried out in mouse models showed that ingestion of high doses of sulforaphane produced: marked sedation (at 150–300 mg/kg), hypothermia (at 150–300 mg/kg), impaired motor coordination (at 200–300 mg/kg), decreased skeletal muscle strength (at 250–300 mg/kg) and deaths (at 200–300 mg/kg)