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Phase I Detoxification Genes: CYP450 Family Many toxicants – whether ingested, inhaled, or created in our bodies – are broken down by the Cytochrome P450 (CYP450) family of enzymes in phase I detoxification

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In addition, the microglia themselves, which are involved in the phagocytosis of dead cells and pathogens, produce O 2 · − and NO when activated [87,88]