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Specifically, MnWO X -PEG exhibited significantly time-dependent GSH consumption capacity through reducing W 6+ to W 5+ (Figure 6E), cooperating with increased ROS to achieve a powerful inhibition effect on tumors (Figure 6F)

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This hypothesis has been confirmed later by the Alpha-Tocopherol/Beta-Carotene (ATBC) trial in Finland organized by the National Cancer Institute NIH (ATBC Trial 1996)