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MOTS-c activate the TGF-β/Smad signaling pathway by up-regulating the expression level of TGF-β1/β2 and Smad7, promoting the synthesis of type I collagen in osteoblasts, and thereby improving osteoporosis [45]

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Looking ahead, future research is crucial to further understand the precise mechanisms by which estrogen impacts brain function and to develop safer, more effective therapies