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On the one hand, periodontitis can influence the development and state of chronic systemic inflammation, through the aberrant increase in proinflammatory cytokines, such as IL-1β, IL-6 and TNF-α, affecting endothelial function, and substantially contributing to the development of insulin resistance, causing a homeostatic imbalance in blood glucose regulation (Acharya et al., 2017)

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31, 141–150.10.1097/WNF.0b013e3181342f32 129 JeerakathilT.JohnsonJ