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Elevated GH — even pituitary-derived GH stimulated by secretagogues — can worsen insulin sensitivity transiently, particularly in the first 4–8 weeks of therapy.9 Adults with existing insulin resistance or prediabetes require close glucose monitoring

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It serves as an obligate co-substrate for multiple enzyme families, including glutathione peroxidases (GPx), glutathione S-transferases (GST), and glutaredoxins, where it contributes to redox-regulated biochemical pathways and enzyme-mediated signaling processes