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SKN103, another LAT1 inhibitor, suppresses the growth of PANC-1 cells, and its combination with cisplatin enhances growth inhibition of cancer cells [74]

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This activation promotes ADP and thromboxane A 2 (TXA 2 )-mediated amplification and thrombin-dependent inositol 1,4,5-trisphosphate receptor (IP 3 R)-driven Ca 2+ release from dense tubular stores (DTS), resulting in a transient rise in cytosolic Ca 2+ (Jardin et al., 2007