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[481 482 483 484] The AHC Model is one of the first Federal pilots to systematically test whether identifying and addressing core HRSNs improves healthcare costs, utilization, and outcomes with 29 participating bridge organizations

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Therefore, as shown in Table 2, various types of nanoparticles including nanoemulsions/microemulsions, lipid nanoparticles, vesicular nanocarriers, polymeric nanoparticles, and gold nanoparticles were utilized to enhance skin permeation, improve drug solubility, increase photostability, control the drug release profile, induce longer drug deposition within the skin layers, and therefore enhance the clinical effectiveness of the therapeutic options for melasma treatment