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BPC-157 appears to activate VEGFR2 and nitric oxide synthesis through the Akt-eNOS axis, along with ERK1/2 signalling, which would matter most in poorly vascularised tissue such as tendon and the myotendinous junction (McGuire et al., Current Reviews in Musculoskeletal Medicine, 2025)

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10.1080/09546630310019346 [DOI] [PubMed] [Google Scholar] 8.Mrowietz U, Szepietowski JC, Loewe R, van de Kerkhof P, Lamarca R, Ocker WG, et al