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These diverse applications confirm that TB-500 mechanisms are not tissue-specific but rather fundamental repair processes that operate across virtually all tissue types

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The combination of BSO+L-PAM achieved synergistic cytotoxicity (combination index number (CIN) ⩽0.7) and induced 2–4 logs of cell kill in all nine MM cell lines including the eight lines established at progressive disease (PD) after therapy (U266, OPM-2, NCI H929, KMS-12-PE, EJM, TX-MM-030h, MM.1S and MOLP-2), 25 which include lines with cytogenetic profiles associated with a poor prognosis (Figure 1b)