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It is also a cofactor in the synthesis of dopamine, histamine, glutamate, and GABA .[ref] Hemoglobin : P5P is needed as a coenzyme in creating heme, which is part of the body’s hemoglobin molecule to carry oxygen through the bloodstream

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The brain, due to its high metabolic activity, is especially susceptible to oxidative stress, and its natural defense mechanisms, like antioxidant enzyme systems, are often inadequate in these diseases