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Exposure to pesticides causes alteration of the inflammatory pathway (Nrf2/NF-kB, MAPKs/PI3K, and Akt/GSK3β) reducing NF-E2–related factor (Nrf)2, increasing NF-kB, and opening voltage-gated Ca2 + channel of the neuron’s plasmatic membrane (Silver et al., 2017), leading to oxidative stress, neuronal apoptosis e reduction of serotonin

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