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Biomarker analyses from a placebo-controlled phase II study evaluating erlotinib +/− onartuzumab in advanced non-small cell lung cancer: MET expression levels are predictive of patient benefit

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The αv-integrin/NRP-1–targeting peptide CEND-1 produced acceptable safety, drug-delivery biology, and encouraging activity in a first-in-human, open-label study with nab-paclitaxel/gemcitabine, 289 and dedicated pharmacokinetic/disposition studies support its mechanism and scheduling